Efficacy Evaluation of Chlorella pyrenoidosa Extracts on Cytotoxicity Induced by Atmospheric Particulate Matter 2.5 Exposure Using Skin Cell Lines and Zebrafish Models

The invention and use of chelating purification products directed at atmospheric particulate matter 2.5 (PM2.5) are beneficial in preventing cytotoxicity bodily harm. However, natural plant active compounds that minimize the adverse effect PM2.5 rarely reported. Chlorella pyrenoidosa extracts (CPEs), a nutritional supplement derived from vulgaris, have been shown to antioxidant anti-inflammatory effects. Here, we discovered CPEs extracted with crushing cell extraction technology can attenuate negative impacts PM2.5. Furthermore, CPE intervention protect against DNA damage unstable genomic structure due exposure. Moreover, restored mRNA protein expression misincorporation repair mechanism gene, nudix hydrolase 1 (NUDT1), 8-oxoguanine glycosylase (OGG1). In vivo protection experiments revealed reduced PM2.5-induced hepatotoxicity zebrafish larvae effectively prevented death adult exposed Briefly, cytotoxicity, resist damage, relieve hepatotoxicity, improve activity, making them ideal for as protective factor or functional ingredient cosmetics health food industries.